CF researchers fight license

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Finding new medicines to fight CF: multiple steps of a success story

Background Cystic fibrosis (CF) is a major life-limiting genetic disease leading to severe respiratory symptoms caused by mutations in CF trans membrane conductance regulator (CFTR), a chloride channel expressed at the apical membrane of epithelial cells. Absence of functional CFTR from the surface of respiratory cells reduces mucociliary clearance, promoting airways obstruction, chronic infect...

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Class 1 CF Mutations

Since the discovery of the gene that causes Cystic Fibrosis, our knowledge of how mutations in this gene cause the varied pathophysiological manifestations of this disease has increased substantially. This knowledge has led to the possibility of new therapeutic approaches aimed at the basic defect. Class I mutations of CFTR include premature termination codons (PTCs) or stop codons. In the last...

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License GPL (> = 2)

October 4, 2013 Type Package Title Gene selection based on the marginal distributions of gene profiles that characterized by a mixture of three-component multivariate distributions Version 2.4.0 Date 2012-11-14 Author Jarrett Morrow , Weiliang Qiu , Wenqing He , Xiaogang Wang , Ross Lazarus <ros...

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PDFlib GmbH license guide

The following additional resources may be useful for your procurement process: > All products have a dedicated purchase order form with prices and licensing details. The purchase order forms are included in each software package and are available from the PDFlib Web site. > The product datasheets on the PDFlib Web site contain a more detailed description of the product functionality and deploym...

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ژورنال

عنوان ژورنال: Nature Biotechnology

سال: 1993

ISSN: 1087-0156,1546-1696

DOI: 10.1038/nbt0193-23